生物活性
Sancycline像其他四环素类药物一样，三环素通过可逆地结合到30S核糖体亚单位并通过阻断氨酰tRNA进入核糖体A位点来抑制蛋白质翻译。
化学数据
| 目录号 | A13393 |
| M. Wt | 414.42 |
| Formula | C21H22N2O7 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 808-26-4 |
| Synonyms | Bonomycin, Norcycline |
| SMILES | CN(C)C1C2CC3CC4=C(C(=CC=C4)O)C(=C3C(=O)C2(C(=C(C1=O)C(=O)N)O)O)O |
溶解度
| In vitro | DMSO | 76 mg/mL (183.39 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 24.13 mL | 120.65 mL | 241.3 mL |
| 0.5 mM | 4.83 mL | 24.13 mL | 48.26 mL |
| 1 mM | 2.41 mL | 12.07 mL | 24.13 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
*The above data is based on the productmolecular weight 414.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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