OtenzePAD 是 M2 mAChR 的特异性拮抗剂，对大鼠心脏和兔外周肺的 IC50 分别为 386 nM 和 640 nM。

Otenzepad is a selective antagonist of M2 mAChR with IC50s of 386 nM and 640 nM for rat heart and rabbit peripheral lung.

In rats, Otenzepad (2 mg/kg; s.c.) significantly improved retention relative to vehicle controls. Otenzepad (0.5, 1 mg/kg; s.c.) significantly improved win-stay acquisition[1]. In mice, Otenzepad (0.3, 1.0, or 3.0 mg/kg, i.p.) reverses the effects of insulin on memory and potentiates the effects of glucose[2].

102394-31-0

C24H31N5O2

421.54

AF-DX 116

DMSO:24 mg/mL (56.93 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years