Asoxime dichloride 是乙酰胆碱受体 (AChRs) 拮抗剂,包括烟碱受体,α7 乙酰胆碱受体。Asoxime dichloride 参与调节免疫应答。Asoxime dichloride 可作为抗原使用,改善神经系统的免疫效果。
产品描述
Asoxime dichloride is an antagonist to acetylcholine receptors (AChRs) including the nicotinic receptor, α7 nAChR. Asoxime dichloride (HI-6) can be used as an antigen and improves vaccination efficacy in the nervous system. Asoxime dichloride involves in modulating immunity response.
体内活性
A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant[1]. Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1 mg/kg[1].
Cas No.
34433-31-3
分子式
C14H16ClN4O3
分子量
323.76
别名
HI-6;Asoxime (dichloride);Tert-Butyl2-(2-hydroxyethyl)-1-pyrrolidinecarboxylate
储存和溶解度
H2O:10 mg/mL (27.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years