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Solifenacin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Solifenacin图片
CAS NO:242478-37-1
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
索利那新
YM905 free base
产品介绍
Solifenacin 是一种新型的毒蕈碱受体拮抗剂,对M1、M2和M3受体的pKi值分别为 7.6、6.9 和 8.0。

产品描述

Solifenacin (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively.

体内活性

The inhibitory effects of Solifenacin on salivary and cardiac responses are only slight at 630 nmol/kg (0.3 mg/kg), and reach 66% and 49%, respectively, at 2100 nmol/kg (1 mg/kg). Solifenacin slightly increases saliva secretion at doses of 63 and 210 nmol/kg (0.03 and 0.1 mg/kg). However, Solifenacin reduces bladder responses by 40% at a dose of 210 nmol/kg (0.1 mg/kg) and abolishes them at 2100 nmol/kg (1 mg/kg). Solifenacin (0.01 to 0.3 mg/kg i.v.) dose-dependently increases bladder capacity and voided volume at doses of 0.03 mg/kg i.v. or more, but does not affect residual volume or micturition pressure at any dose tested.

Cas No.

242478-37-1

分子式

C23H26N2O2

分子量

362.473

别名

索利那新;YM905 free base

储存和溶解度

DMSO:49 mg/mL (135.18 mM)
H2O:< 0.1 mg/mL (insoluble)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years