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L-Glutamine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Glutamine图片
CAS NO:56-85-9
包装与价格:
包装价格(元)
50 mg电议
1 mL*10 mM(in Water)电议

产品名称
L-谷氨酰胺
L-Glutamic acid 5-amide
产品介绍
L-Glutamine 是在人体中大量存在的一种非必需氨基酸,由谷氨酸和氨合成。它为某些细胞中的氧化提供了碳源。

产品描述

L-glutamine, a non-essential amino acid, is synthesized from glutamic acid and ammonia.

体外活性

L-Glutamine (0.2 and 2 mM) but not D-Gln inhibits the generation of L-Arg by both Arg-depleted and nondepleted endothelial cells. L-Glutamine also inhibits the conversion of L-[14C]Cit to L-[14C]Arg by Arg-depleted endothelial cells. L-Glutamine interferes with the conversion of L-Cit to L-Arg probably by acting on argininosuccinate synthetase rather than argininosuccinate lyase. L-Glutamine also inhibits the generation of L-Arg by the monocyte-macrophage cell line J774 but has no effect on the conversion of L-Cit to L-Arg by these cells. [1] L-Glutamine metabolism stimulates Na+-H+exchange of acid-loaded porcine enterocytes by a mechanism not requiring activation of PKC. [2] L-Glutamine (0.2 mM and 2 mM) but not D-glutamine (2 mM), L-glutamic acid (2 mM) or ammonium chloride (1 mM) also inhibits the generation of L-arginine in endothelial cells. [3] L-glutamine promotes chromatin condensation and formation of crescent-like structures in the nucleus of murine primary microglia as well as of the microglial cell-line BV-2. [4]

体内活性

L-Glutamine at 0.5, 2 and 5 mM dose-dependently reduces H(2)O(2)- or LPS-induced cell death by 14%, 54% and 95%. L-Glutamine increases Glutamine concentrations in small-intestinal lumen and plasma, reduces intestinal expression of Toll-like receptor-4, active caspase-3 and NFkB, ameliorates intestinal injury, decreases rectal temperature, and enhanced growth performance in LPS-challenged piglets. [5]

Cas No.

56-85-9

分子式

C5H10N2O3

分子量

146.14

别名

L-谷氨酰胺;L-Glutamic acid 5-amide

储存和溶解度

DMSO:Insoluble
H2O:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years