您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Hemin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Hemin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hemin图片
CAS NO:16009-13-5
包装与价格:
包装价格(元)
500 mg电议
1 g电议
1 mL*10 mM(in DMSO)电议

产品名称
氯化血红素
Hemin chloride
产品介绍
Hemin 是一种含铁卟啉和血红素加氧酶 (HO)-1 诱导剂。

产品描述

Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.

体外活性

Hemin treatment decreased cell proliferation to 62±5 %, 51±3 %, and 38±8 % in PA-TU-8902, BxPC-3 and MiaPaCa-2 cancer cells, respectively, with p<0.0001 for all comparisons. Furthermore, we observed enhancement of anti-proliferative effects of statins by hemin, documented as decreased cell proliferation after 48 h of co-treatment[1][2].

细胞实验

In vitro effects of various statins and hemin, a heme oxygenase inducer, on cell proliferation were evaluated in PA-TU-8902, MiaPaCa-2 and BxPC-3 human pancreatic cancer cell lines. The effect of statins on heme oxygenase activity was assessed and heme oxygenase-silenced cells were used for pancreatic cancer cell proliferation studies. Cell death rate and reactive oxygen species production were measured in PA-TU-8902 cells, followed by evaluation of the effect of cerivastatin on GFP-K-Ras trafficking and expression of markers of invasiveness, osteopontin (SPP1) and SOX2[1].

Cas No.

16009-13-5

分子式

C34H32ClFeN4O4

分子量

651.95

别名

氯化血红素;Hemin chloride

储存和溶解度

DMSO:6.5 mg/mL (10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years