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Gemigliptin Tartrate(911637-19-9 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gemigliptin Tartrate(911637-19-9 free base)图片
CAS NO:1374639-74-3
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
吉格列汀酒石酸盐
LC15-0444 tartrate
产品介绍
Gemigliptin tartrate 是一种选择性的,可逆的,竞争性的二肽基肽酶 4 (DPP-4) 抑制剂,对于人重组 DPP-4 的IC50=10.3 nM。Gemigliptin tartrate具有很强的抗糖基化活性,能够用于晚期糖基化终产物相关的糖尿病并发症的研究。

产品描述

Gemigliptin tartrate is a highly selective, reversible and competitive inhibitor of dipeptidyl peptidase-4 (DPP-4). It has an IC50 of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties.

体外活性

Gemigliptin tartrate inhibits the formation of AGE-BSA with IC50 of 11.69 mM[1]. Gemigliptin tartrate suppresses the cross-linking of preformed AGE-BSA with rat tail tendon collagen with an IC50 of 1.39 mM[1]. Gemigliptin tartrate is a competitive DPP-4 inhibitor with a Ki of 7.25 nM[2].

体内活性

Gemigliptin tartrate inhibits AGEs formation and AGE cross-links in vivo[1]. Gemigliptin tartrate dose-dependently inhibits plasma DPP-4 activity in rats, dogs, and monkeys[2].

Cas No.

1374639-74-3

分子式

C22H25F8N5O8

分子量

639.45

别名

吉格列汀酒石酸盐;LC15-0444 tartrate

储存和溶解度

DMSO:90mg/ml(140.75mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years