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S63845
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
S63845图片
CAS NO:1799633-27-4
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
S63845 是一种选择性骨髓细胞白血病 1 抑制剂,结合人MCL1的Kd值为 0.19 nM。

产品描述

S63845 is a selective MCL-1 inhibitor(Kd: 0.19 nM)

体外活性

S63845, a small molecule that specifically binds with high affinity to the BH3-binding groove of MCL1.?S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway[1].

体内活性

In vivo, S63845 shows potent anti-tumour activity with an acceptable safety margin as a single agent in several cancers.?Moreover, MCL1 inhibition, either alone or in combination with other anti-cancer drugs, proved effective against several solid cancer-derived cell lines.?MCL1 as a target for the treatment of a wide range of tumours[1].

Cas No.

1799633-27-4

分子式

C39H37ClF4N6O6S

分子量

829.26

储存和溶解度

DMSO:33.33 mg/mL (40.19 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years