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BH3I-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BH3I-1图片
CAS NO:300817-68-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品名称
BHI1
产品介绍
BH3I1 是一种BCL-2家族拮抗剂,作用于p53/Mdm2,Kd为 5.3 μM。它抑制BakBH3 肽与BCL-xL结合,Ki为 2.6 μM。

产品描述

BH3I-1 is a Bcl-2 antagonist.

体外活性

BH3I-1 inhibits Bcl-xL heterodimerization in vitro. It also induces cytochrome c release[1]. BH3I-1, while inhibiting its reported target Bcl-2/Bim and Bcl-xL/Bim, shows significant inhibition of both the p53/hDM2 and p300/Hif-1a interactions[2].

细胞实验

Cells (5×104 cells per well) are seeded into white 96-well plates (Costar) and treated with various concentrations of the compounds for 48 h. For zVAD-FMK protection experiments, cells are preincubated with 100 μM zVAD-FMK for 1 h before the addition of chemicals. Cell viability is determined with an MTS assay. For PI staining experiments, cells are grown in 24-well plates and then incubated with 2 μg ml/L PI. Cell death is determined by FACS analysis.(Only for Reference)

Cas No.

300817-68-9

分子式

C15H14BrNO3S2

分子量

400.31

别名

BHI1

储存和溶解度

H2O:<1 mgml
Ethanol:11 mg/mL (27.5 mM)
DMSO:60 mg/mL (149.9 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years