ML311 是 Mcl-1/Bim 相互作用的一种选择性抑制剂。

ML311 is a selective inhibitor of the Mcl-1/Bim interaction.

ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50: 0.31 μM), NCI-H929 (EC50: 1.6 μM), and DHL-6 (EC50: 3.3 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50: 1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and<2 μM for 14 additional types[1].

315698-17-0

C23H24F3N3O

415.46

H2O:Insoluble
DMSO:20 mg/mL
Ethanol:20 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years