SW-106065 是一种恶性外周神经鞘瘤（MPNST）细胞凋亡诱导剂。 它抑制 sMPNST 和其他 MPNST 模型的 ATP 消耗，EC50 为 1 μM。

SW-106065 is a novel pharmacologic inducer of apoptosis in MPNST (malignant peripheral nerve sheath tumors).SW106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST). It inhibits ATP consumption of sMPNST and other models of MPNST with an EC50 of 1 μM. SW106065 can be used for MPNST research

SW-106065 inhibits growth of all available in vitro models of MPNST and human MPNST cell lines, while remaining nontoxic to normally dividing Schwann cells or mouse embryonic fibroblasts. We This compound delays the cell cycle and leads to cellular apoptosis.

SW-106065 can reduce MPNST burden in a mouse allograft model, underscoring the compound's potential as a novel chemotherapeutic agent.

62289-81-0

C10H8N2OS

204.25

SW-106065

DMSO:96 mg/mL (470 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years