Taurodeoxycholic acid sodium hydrate 通过阻断钙介导的凋亡通路和 Caspase-12的活化来阻止细胞凋亡。它可用于原发性胆汁性肝硬化、胰岛素抵抗、淀粉样变性、囊性纤维化、胆汁淤积和肌萎缩侧索硬化症。

Taurohyodeoxycholic acid sodium salt, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.

At all infusion rates, taurohyodeoxycholic acid caused a greater (P< 0.001) secretion of biliary lecithin compared to the other bile salts. There were no significant differences in the biliary secretion of cholesterol and proteins. Electron microscopy showed the recruitment of vesicles and lamellar bodies around and within bile canaliculi. In conclusion, taurohyodeoxycholic promotes a biliary lecithin secretion greater than expected from physicochemical predictions, representing a novel secretory property with potential pharmacological relevance[1].

110026-03-4

C26H46NNaO7S

539.70

牛磺猪去氧胆酸;Sodium taurodeoxycholate monohydrate;Taurodeoxychloic Acid sodium hydrate;Taurohyodeoxycholic acid sodium salt

DMSO:125 mg/mL (231.18 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years