Emricasan 是一种不可逆的泛半胱天冬酶抑制剂。它抑制 Zika 病毒诱导的Caspase-3活性增加,有保护神经作用。
产品描述
Emricasan is an effective and irreversible pan-caspase inhibitor.
体外活性
Emricasan (IDN-6556 or PF-03491390) is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan has a neuroprotective activity for hNPCs but does not inhibit ZIKV replication.
体内活性
Emricasan reduces liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, Emricasan can attenuate stellate cell activation and hepatic fibrogenesis.
细胞实验
Astrocytes are mock-infected, treated with DMSO or treated with 2 μM niclosamide, 92 μM PHA-690509, 9 μM emricasan, or a combination of 92 μM PHA-690509 and 9 μM emricasan for 1 h before infection with PRVABC59 (MOI = 0.5). Cells are fixed 24 h after infection and stained for ZIKVE and nuclei.(Only for Reference)
Cas No.
254750-02-2
分子式
C26H27F4N3O7
分子量
569.51
别名
恩利卡生;IDN-6556;PF 03491390
储存和溶解度
Ethanol:93 mg/mL (163.3 mM)
H2O:<1 mgml
DMSO:93 mg/mL (163.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years