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Emricasan
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Emricasan图片
CAS NO:254750-02-2
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
恩利卡生
IDN-6556
PF 03491390
产品介绍
Emricasan 是一种不可逆的泛半胱天冬酶抑制剂。它抑制 Zika 病毒诱导的Caspase-3活性增加,有保护神经作用。

产品描述

Emricasan is an effective and irreversible pan-caspase inhibitor.

体外活性

Emricasan (IDN-6556 or PF-03491390) is an inhibitor of activated caspases, and it has sub- to nanomolar activity in vitro. Emricasan has a neuroprotective activity for hNPCs but does not inhibit ZIKV replication.

体内活性

Emricasan reduces liver injury but not metabolic derangement in NASH. It also ameliorates inflammation. In the murine NASH model, Emricasan can attenuate stellate cell activation and hepatic fibrogenesis.

细胞实验

Astrocytes are mock-infected, treated with DMSO or treated with 2 μM niclosamide, 92 μM PHA-690509, 9 μM emricasan, or a combination of 92 μM PHA-690509 and 9 μM emricasan for 1 h before infection with PRVABC59 (MOI = 0.5). Cells are fixed 24 h after infection and stained for ZIKVE and nuclei.(Only for Reference)

Cas No.

254750-02-2

分子式

C26H27F4N3O7

分子量

569.51

别名

恩利卡生;IDN-6556;PF 03491390

储存和溶解度

Ethanol:93 mg/mL (163.3 mM)
H2O:<1 mgml
DMSO:93 mg/mL (163.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years