您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Tauroursodeoxycholate sodium
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Tauroursodeoxycholate sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:35807-85-3
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Tauroursodeoxycholic acid sodium salt
牛磺熊去氧胆酸钠
牛磺熊脱氧胆酸钠
TUDC
Sodium tauroursodeoxycholate
Sodium Tauroursodeoxycholate (TUDC)
产品介绍
Tauroursodeoxycholate sodium是一种内质网应激抑制剂。Tauroursodeoxycholate 抑制ERK,显著降低凋亡分子表达,如Caspase-3和Caspase-12。

产品描述

Tauroursodeoxycholate Sodium is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.

体内活性

In phalloidin-induced cholestasis rats, Tauroursodeoxycholate (360 μmol/kg, i.v.) significantly suppresses the decrease in bile flow and increases in serum alkaline phosphatase, leucine aminopeptidase and glutamic pyruvic transaminase activities, cholesterol, phospholipid and bile acid concentrations. [2]

细胞实验

Cell lines: Mz-ChA-1 cells. Concentrations: ~200 μM. Method: After trypsinization,Mz-ChA-1 cells are suspended in CCM at 5×104 cells/mL,and 200 μL of the cell suspension is seeded into 96-well plates.After an initial incubation step of 4 h at 37°C in a 5% CO2 incubator,the cells are incubated at 37°C with TUDCA (0.2–200 μM).After incubation for 24–96 h,[3H]thymidine is put into each well at 5.0 μCi/mL and incubated for additional 4 h.[3H]thymidine incorporation is measured by a scintillation counter.

动物实验

Animal Models: Phalloidin-induced cholestasis ratsFormulation & . Dosages: Saline; 360 μMol/kg. Administration: intravenous injection

Cas No.

35807-85-3

分子式

C26H44NNaO6S

分子量

521.69

别名

Tauroursodeoxycholic acid sodium salt;牛磺熊去氧胆酸钠;牛磺熊脱氧胆酸钠;TUDC;Sodium tauroursodeoxycholate;Sodium Tauroursodeoxycholate (TUDC)

储存和溶解度

Ethanol:10 mg/mL(19.2 mM)
DMSO:93 mg/mL (178.3 mM)
H2O:92 mg/mL (176.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years