AMG-47a 是具有口服活性的Lck抑制剂，IC50值为 0.2 nM。它具有抗炎作用，对VEGF2、p38α、p38α、JAK3、MLR和IL-2的IC50值分别为 1、3、72、30 和 21 nM。

AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.

882663-88-9

C29H28F3N5O2

535.571

DMSO:34 mg/mL (63.48 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years