WHI-p97 是一种选择性JAK-3抑制剂，可用于预防过敏性哮喘的研究。

WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal.

211555-05-4

C16H13Br2N3O3

455.106

4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years