Itacitinib 是一种选择性JAK1抑制剂，对 人JAK1的IC50值为 2 nM。它对JAK1选择性是 JAK2 的 20 倍多，是 JAK3 和 TYK2 的 100 倍多。

Itacitinib is an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic activity.

Itacitinib is an inhibitor of the Janus kinases (JAKs) with selectivity for JAK1.

Itacitinib (INCB039110) produced significant improvements in sPGA, demonstrating proof of concept in chronic plaque psoriasis.

1334298-90-6

C26H23F4N9O

553.526

INCB39110;伊他替尼;INCB039110

DMSO:30 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years