GDC046 是一种具有口服活性的选择性TYK2抑制剂，对 TYK2、JAK1、JAK2 和 JAK3 的Ki分别为 4.8、0.7、0.7 和 0.4 nM。

GDC046, a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.

1258292-64-6

C16H13Cl2N3O2

350.2

GDC046

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years