Brepocitinib P-Tosylate 是一种有效的JAK1和TYK2双重抑制剂，IC50值分别为 17 和 23 nM。它还抑制JAK2和JAK3，IC50值分别为 77 和 6.49 μM。

PF-06700841 P-Tosylate is a potent dual inhibitor of Janus kinase 1 (JAK1) and TYK2 (IC50s of 17 nM and 23 nM, respectively).

PF-06700841 has good potency against IL6/pStat1 in the CD3+ cellular subset (IC50 of 81 nM), but lower inhibition of IL6/pSTAT3, again in the CD3+ cellular subset (IC50 of 641 nM).

PF-06700841 (oral administration; for 7 consecutive days; female Lewis rats) treatment significantly reduces paw volume increase in a dose-dependent manner[1].

2140301-96-6

C25H29F2N7O4S

561.6

PF-06700841 P-Tosylate

DMSO:59 mg/mL (105.05 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years