IMR1 是一种Notch抑制剂，IC50=26 μM。它能够阻止 Maml1 募集到染色质上的 Notch 三元复合体 (NTC)，抑制 Notch 靶基因转录，具有抗肿瘤活性。

IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.

ChIP assay on the HES1 promoter using the indicated antibodies following treatment of OE33 and 786-0 cells with DAPT (15 μM), IMR-1 (25 μM), or vehicle (DMSO) using GAPDH as loading control. (Only for Reference)

310456-65-6

C15H15NO5S2

353.41

Ethanol:<1 mgml
DMSO:65 mg/mL (183.9 mM)
H2O:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years