Aftin4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。
产品描述
Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.
动物实验
Brains of 4-mo-old C57BL/6 wild-type mice were dissected and mechanically disassociated in HBSS with a tissue homogenizer. Aliquots from each mouse were incubated with DMSO and two concentrations of Aftin-4 at 37°C for 3 h. Liquefied brains were sonicated and centrifuged at 13,000 rpm for 15 min. WB analysis was performed using CT695 antibody for soluble Aβ-CTF. They are for reference only.
Cas No.
866893-90-5
分子式
C20H28N6O
分子量
368.485
别名
Aftin4;Aftin 4
储存和溶解度
DMSO:25 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years