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Aftin-4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aftin-4图片
CAS NO:866893-90-5
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Aftin4
Aftin 4
产品介绍
Aftin4 是一种 β-淀粉样蛋白42(Aβ42) 的诱导剂。

产品描述

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer's disease-like toxicity in the rodent brain.

动物实验

Brains of 4-mo-old C57BL/6 wild-type mice were dissected and mechanically disassociated in HBSS with a tissue homogenizer. Aliquots from each mouse were incubated with DMSO and two concentrations of Aftin-4 at 37°C for 3 h. Liquefied brains were sonicated and centrifuged at 13,000 rpm for 15 min. WB analysis was performed using CT695 antibody for soluble Aβ-CTF. They are for reference only.

Cas No.

866893-90-5

分子式

C20H28N6O

分子量

368.485

别名

Aftin4;Aftin 4

储存和溶解度

DMSO:25 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years