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Triparanol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Triparanol图片
CAS NO:78-41-1
包装与价格:
包装价格(元)
1 mg电议
2 mg电议
5 mg电议
10 mg电议
100 mg电议

产品名称
曲帕拉醇
NSC65345
NSC 65345
NSC-65345
产品介绍
Triparanol 干扰 Hedgehog 信号分子的翻译后修饰以及其受体 PTCH1 的甾醇传感域,导致 Hedgehog 信号的下调。 Triparanol 抑制人类肿瘤生长,是一种具有高眼毒性的抗血脂剂。

产品描述

Triparanol interferes with posttranslational modification of Hedgehog signaling molecules as well as the sterol sensing domain of its receptor PTCH1, leading to down-regulation of Hedgehog signaling. Triparanol suppresses human tumor growth and is an antilipemic agent with high ophthalmic toxicity.

体外活性

Triparanol is an effective cholesterol biosynthesis inhibitor blocking the 24-dehydrocholesterol reductase. Triparanol can block proliferation and induce apoptosis in multiple human cancer cells including lung, breast, liver, pancreatic, prostate cancer, and melanoma cells, and growth inhibition can be rescued by the exogenous addition of cholesterol[2].

Cas No.

78-41-1

分子式

C27H32ClNO2

分子量

438

别名

曲帕拉醇;NSC65345;NSC 65345;NSC-65345

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years