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Pentabromophenol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pentabromophenol图片
CAS NO:608-71-9
包装:5 mg
市场价:287元

产品名称
五溴苯酚
NSC5717
NSC-5717
NSC 5717
产品介绍
Pentabromophenol 通过加速 TGF-β 受体的转换率来抑制 TGF-β 反应。

产品描述

Pentabromophenol suppressed TGF-β response by accelerating the turnover rate of TGF-β receptors.

体外活性

Following 18hr exposure of murine BV-2 cells, at dose levels resulting in ≥80% viability (10 and 40 μM), limited alterations in pro-inflammatory responses were observed however, changes were observed in mitochondrial respiration. Basal respiration, ATP-linked respiration, maximum respiration, basal glycolytic and compensatory glycolysis were altered by Pentabromophenol. Phagocytosis was decreased for Pentabromophenol and TBBPA. NLRP3 inflammasome activation was assessed using BV-2-ASC (apoptosis-associated speck-like protein containing a CARD) reporter cells to visualize aggregate formation. Pentabromophenol, showed a direct stimulation of aggregate formation and properties as a NLRP3 inflammasome secondary trigger[1].

Cas No.

608-71-9

分子式

CHBr5O

分子量

488.59

别名

五溴苯酚;NSC5717;NSC-5717;NSC 5717

储存和溶解度

DMSO:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years