Adavivint (SM04690) 是选择性的典型的Wnt信号通路抑制剂，在 SW480 细胞中，用高通量 TCF/LEF 报告基因实验，测得EC50=19.5 nM。

Adavivint (SM04690) is a Wnt pathway inhibitor.

Adavivint (SM04690) is a?novel Wnt pathway inhibitor, for the treatment of moderate to severe osteoarthritis of the knee.

A high-throughput screen was performed using a cell-based reporter assay for Wnt pathway activity to develop a small molecule designated SM04690. Its properties were evaluated in bone-marrow-derived human mesenchymal stem cells (hMSCs) to assess chondrocyte differentiation and effects on cartilage catabolism by immunocytochemistry and gene expression, and glycosaminoglycan breakdown. In vivo effects of SM04690 on Wnt signaling, cartilage regeneration and protection were measured using biochemical and histopathological techniques in a rodent acute cruciate ligament tear and partial medial meniscectomy (ACLT + pMMx) OA model.

1467093-03-3

C29H24FN7O

505.557

Adavivint (SM04690)

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years