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Pyrvinium pamoate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pyrvinium pamoate图片
CAS NO:3546-41-6
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
扑蛲灵
Pyrvinium embonate
产品介绍
Pyrvinium pamOATe 是一种古老的驱虫药,用于治疗蛲虫病,由于其在某些类型的癌症中抑制 Wnt/β-CATenin 通路,它作为抗癌药物再次引起人们的关注。

产品描述

Pyrvinium pamoate is an old anthelminthic medicine for the treatment of enterobiasis , which re-attracts attention as an anti-cancer drug due to its inhibition of Wnt/β-catenin pathway in some types of cancer.

体外活性

Pyrvinium pamoate treatment repressed the phosphorylation of GSK3β at S9 which might be mediated by AKT, and decreased the protein levels of β-catenin and its downstream targets (c-Myc, cyclin D1). Pyrvinium pamoate remarkably inhibited cell viability and colony formation ability. Treatment with pyrvinium pamoate induced intrinsic pathway-dependent apoptosis accompanied with a decline of anti-apoptotic XIAP and Survivin, and an overt increase of pro-apoptotic Bax. In addition, pyrvinium pamoate significantly inhibited the migration and invasion in vitro[1].

Cas No.

3546-41-6

分子式

C75H70N6O6

分子量

1151.421

别名

扑蛲灵;Pyrvinium embonate

储存和溶解度

DMSO:24 mg/mL (41.69 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years