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ISX-9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ISX-9图片
CAS NO:832115-62-5
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Isoxazole 9
Isoxazole 9 (ISX-9)
产品介绍
ISX-9 是一种神经干细胞分化的有效诱导剂,可诱导 Notch 激活的心外膜衍生细胞 (NEC) 的心肌分化。它可通过电压门控的 Ca2+通道和 NMDA 受体来激活 Ca2+流入,并增加 NeuroD 表达。

产品描述

ISX9 is necessary to activate neuron-specific genes as neurogenesis inducer.

体外活性

In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs. [1]

体内活性

In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory. [2]

细胞实验

Cells are treated with different concentrations of Isx-9 (0, 6.25, 12.5, 25, or 50 μM), and 2 days later, cell numbers are counted in a blinded manner to evaluate the effects of Isx-9 on the proliferation/survival of four types of progenitor/precursor cells.(Only for Reference)

Cas No.

832115-62-5

分子式

C11H10N2O2S

分子量

234.27

别名

Isoxazole 9;Isoxazole 9 (ISX-9)

储存和溶解度

Ethanol:11 mg/mL (47 mM)
DMSO:43 mg/mL (183.5 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years