C-82 是一种特异性 CBP/β-CATenin 拮抗剂。它抑制 β-CATenin 和 CBP 之间的结合，并增加 β-CATenin 和 p300 之间的结合。

C-82 is a specific CBP/β-catenin antagonist. It inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300.

C-82 inhibits the activation of isolated primary mouse quiescent hepatic stellate cells (HSCs) and promotes cell death in culture-activated HSCs.

PRI-724 is phosphorylated-C-82 and is rapidly hydrolyzed to its active form C-82 in vivo, and pre-clinical studies have shown a very acceptable toxicity profile.

1422253-37-9

C33H34N6O4

578.66

DMSO:55 mg/ml (95.05 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years