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A 1070722
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
A 1070722图片
CAS NO:1384424-80-9
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
A 1070722 是高效的糖原合成酶激酶 3 (GSK-3)选择性抑制剂,与 GSK-3α 和 GSK-3β 结合的Ki为 0.6 nM。A 1070722 可以穿透血脑屏障并在脑区积聚,具有作为PET 放射性跟踪剂定量测定脑部 GSK-3的潜力。

产品描述

A 1070722 is a potent and selective GSK-3 inhibitor, shows high affinity GSK-3α(Ki = 0.6 nM) and GSK-3β(Ki = 0.6 nM). It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for the quantification of GSK-3 in brain.

体内活性

PET imaging experiments in anesthetized vervet/African green monkey exhibited that A 1070722 penetrated the blood-brain barrier (BBB) and accumulated in brain regions, with highest radioactivity binding in frontal cortex followed by parietal cortex and anterior cingulate, and with the lowest bindings found in caudate, putamen, and thalamus, similarly to the known distribution of GSK-3 in human brain[1].

Cas No.

1384424-80-9

分子式

C17H13F3N4O2

分子量

362.31

储存和溶解度

DMSO:83.33 mg/mL (230.00 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years