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TDZD-8
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TDZD-8图片
CAS NO:327036-89-5
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
NP 01139
GSK-3β Inhibitor I
产品介绍
TDZD-8 是抑制GSK-3β的抑制剂,其 IC50=2 μM。它对 CDK-1/cyclin?B,CK-II,PKA 和 PKC 的作用较弱,IC50值均 >100 μM。

产品描述

TDZD-8 is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.

体外活性

TDZD-8 acts as a noncompetitive inhibitor of ATP or GS-1 binding. TDZD-8 shows no inhibition of PKA, PKC, Cdk-1/cyclin B or CK-II in kinase assays. [1] TDZD-8 specifically induces cell death of primary leukemia specimens. TDZD-8 ablates leukemia progenitor and stem cells. TDZD-8 treatment induces oxidative stress. TDZD-8 induces cell death with extremely rapid cell death kinetics showing loss of membrane integrity. TDZD-8 inhibits PKC and FLT3 in primary AML specimens. [2]

Cas No.

327036-89-5

分子式

C10H10N2O2S

分子量

222.26

别名

NP 01139;GSK-3β Inhibitor I

储存和溶解度

H2O:<1 mgml
DMSO:44.5 mg/mL (200.21 mM)
Ethanol:44.5 mg/mL (200.21 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years