Indirubin-3-monoxime 是一种有效的细胞周期蛋白依赖性蛋白激酶抑制剂，是 indirubin 的合成衍生物。它可通过激活软骨细胞中的 Wnt/β-CATenin 信号来促进身高增长，可能在阿尔茨海默病的神经元凋亡中发挥作用。

Indirubin-3-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.

clear efficacy of I3M + Tq combinations in LC models mediated by suppressing Akt/mTOR/NFκB signalling.

indirubin-3'-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta 25-35 (Aβ25-35), and also suppressed apoptosis by reducing tau phosphorylation at Ser199 and Thr205.?Furthermore, indirubin-3'-monoxime inhibited phosphorylation of glycogen synthase kinase-3β (GSK-3β).?indirubin-3'-monoxime reduced Aβ25-35-induced apoptosis by suppressing tau hyperphosphorylation via a GSK-3β-mediated mechanism.?Indirubin-3'-monoxime is a promising drug candidate for Alzheimer's disease.

667463-82-3

C16H11N3O2

277.283

Indirubin-3'-monoxime

DMSO:55 mg/ml (198.36 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years