BRD5648 是 BRD0705 的 阴性对照，BRD0705 是旁系选择性和口服有效的 GSK3α 抑制剂，Kd为 4.8 μM，IC50为 66 nM。与 GSK3β (IC50为 515 nM) 相比，BRD0705 对 GSK3α 的选择性更高 (8 倍)。BRD0705 可用于急性髓细胞性白血病。

BRD5648 is an inactive (R)-enantiomer of BRD0705. BRD0705 is a GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM) and can be used in acute myeloid leukemia (AML) studies.

BRD5648 does not induce changes in enzyme phosphorylation or total β-catenin protein stabilization.

2056261-42-6

C20H23N3O

321.42

(R)-BRD0705

DMSO:300 mg/mL (933.36 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years