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Ochromycinone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ochromycinone图片
CAS NO:111540-00-2
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
STA-21
STA 21
STA21
产品介绍
STA21 是一种天然抗生素,也是一种STAT3抑制剂。它可抑制STAT3DNA结合活性,STAT3二聚化。它具有抗癌和抗菌活性。

产品描述

STA-21 is a selective STAT3 inhibitor.

体外活性

In cells, STA-21 inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. STA-21 remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. [1] In RH30 and RD2 cells, STA-21 also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways. [2]

体内活性

In IL-1Ra–KO mice, STA-21 (0.5 mg/kg, i.p.) reduces the arthritis score and the incidence of arthritis by decreasing the proportion of Th17 cells and increasing the proportion of Treg cells expressing FoxP3. [3]

细胞实验

Human breast cancer cell lines MDA-MB-231, MDA-MB-435s, MDA-MB-453, MDA-MB-468, and MCF7, human ovarian carcinoma cell line Caov-3, and human skin fibroblasts were cultured in DMEM containing 10% FBS and appropriate antibiotics in a 5% CO2 incubator at 37°C. For testing different compounds, the cells were exposed to the compounds for 48 h at a final concentration of 20 or 30 μM, respectively. Then, the cells were harvested and subjected to flow-cytometry analysis.(Only for Reference)

Cas No.

111540-00-2

分子式

C19H14O4

分子量

306.317

别名

STA-21;STA 21;STA21

储存和溶解度

DMSO:20 mg/mL (65.3 mM)
H2O:<1 mgml
Ethanol:2 mg/mL (6.52 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years