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Napabucasin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Napabucasin图片
CAS NO:83280-65-3
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
BBI608
产品介绍
Napabucasin 是一种口服的 STAT3 和 Y 干细胞活性抑制剂。

产品描述

Napabucasin is an orally available Stat3 and Y cell stemness inhibitor.

体外活性

Napabucasin downregulates stemness gene expression driven by Stat3 and cancer stemness properties, and effectively inhibits self-renewal of stemness-high cancer cells with IC50 ranged from 0.291~1.19 μM, on inhibition on normal stem cells. [1]

体内活性

In mice bearing PaCa-2 xenografts, Napabucasin (20 mg/kg, i.p.) significantly inhibits tumor growth, relapse and metastasis. [1]

细胞实验

For cancer stem cells, spheres are dissociated and plated under cancer stem cell culture conditions on coated 96-well plates. After 72 h of culture, wells are dosed with the indicated compounds. Seventy-two hours or 24 h after dosing, CellTiter-Glo 2.0 is added to each well, and the luminescence is measured as described by the manufacturer. IC50 values are calculated by fitting a four parameter dose–response curve to normalized data using GraphPad Prism software. For bulk cells, cells are plated at 5,000 cells per well on 96-well plates. Twenty-four hours after plating, cells are treated with the indicated compounds. Viability is determined at 72 h as described above.(Only for Reference)

Cas No.

83280-65-3

分子式

C14H8O4

分子量

240.214

别名

BBI608

储存和溶解度

H2O:<1 mgml
DMSO:10 mg/mL
Ethanol:<1 mgml
Powder: -20°C for 3 years
In solvent: -80°C for 2 years