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Sucralfate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sucralfate图片
CAS NO:54182-58-0
包装与价格:
包装价格(元)
100 mg电议
500 mg电议

产品名称
Sucrose octasulfate–aluminum complex
硫糖铝
产品介绍
Sucralfate 是一种口服活性胃保护剂。它抑制消化性活性,并与黏膜损伤时暴露的带负电荷的上皮下蛋白结合,形成一层粘性层,保护血管床和增殖区。它可用于预防和治疗胃肠道疾病。

产品描述

Sucralfate is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers.

体外活性

Sucralfate may inhibit intestinal epithelial motility by sterically interfering with adhesion to collagen I[3]. It protects RGMl cells from acid- and pepsin-induced damage[4].

体内活性

The protective effects of sucralfate against ARC(acute radiation colitis) may be partially due to the supression of radiation-induced apoptosis by way of p53 in the colon and the protection of the colonic epithelial stem cell region[2].

细胞实验

Sucralfate is dissolved or suspended in culture medium containing 20% FBS. Cells are incubated with the agent at 37°C under 5% CO2, in air for 0.5-4 h. In some cases, cells are treated with 10-5mol/L indomethacin for 4h before the addition of the agent to determine whether or not intracellular prostaglandins are involved in the protective mechanisms of sucralfate. (Only for Reference)

Cas No.

54182-58-0

分子式

C11H407Al9O215S8

分子量

4481.48

别名

Sucrose octasulfate–aluminum complex;硫糖铝

储存和溶解度

H2O:0.4 mg/mL (0.20 mM),ultrasonic and adjust pH to 2 with HCl
DMSO:20.87 mg/ml (10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years