Setipiprant 是一种口服的选择性 CRTH2 拮抗剂，IC50为6.0 nM。

Setipiprant is an orally available, selective CRTH2 antagonist (IC50: 6.0 nM). CRTH2 is a G protein-coupled receptor for prostaglandin (PGD2). PGD2 is produced by the mast cells and is a key mediator in various inflammatory diseases, including allergy and asthma. Binding of PGD2 to CRTH2, which are expressed on the surface of blood-borne cells, induces chemotaxis of Th2 cells, basophils, and eosinophils, and stimulates cytokine release from these cells.

866460-33-5

C24H19FN2O3

402.425

ACT-129968;塞替匹仑;KYTH-105

DMSO:36 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years