N-tert-Butyl-α-phenylnitrone 是基于硝酮的自由基清除剂，可形成一氧化氮自旋加合物。它可以穿透血脑屏障，抑制COX2的催化活性，有ROS清除、抗炎、神经保护、抗衰老和抗糖尿病的作用。

N-tert-butyl-α-Phenylnitrone inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone possesses potent reactive oxygen species scavenging, anti-inflammatory, neuroprotective, anti-aging, and anti-diabetic activities, and can penetrate the blood-brain barrier.

Treatment of 25-100 μM N-tert-butyl-α-Phenylnitrone significantly reduces 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced intracellular ROS accumulation. N-tert-butyl-α-Phenylnitrone also attenuates AAPH-induced cytotoxicity, matrix degradation, and apoptosis, inhibiting AAPH-induced ERK/MAPK pathway activation[1].

In C57Bl/6 mice induced by lipopolysaccharide (LPS), intraperitoneal injection of 100 mg/kg N-tert-butyl-α-Phenylnitrone twice a day (on gestational day 8) abolishes LPS-induced lipid peroxidation, nitrate tyrosine residue levels and GSH depletion, and reduces the incidence of external malformations[2].

3376-24-7

C11H15NO

177.24

N-叔丁基-α-苯基硝酮;(Z)-N-benzylidene-2-Methylpropan-2-aMine oxide

DMSO:50 mg/Ml(282.10 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years