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Clovamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Clovamide图片
CAS NO:53755-02-5
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
N-trans-Caffeoy-L-dopa
trans-Clovamide
产品介绍
Clovamide 是一种天然存在的咖啡酰结合物,具有抗菌、抗炎、抗氧化和神经保护作用。它是一种极好的活性氧和氧自由基清除剂。

产品描述

Trans-Clovamide is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprotective effects (EC50s = 0.9-3.7 μM) in several in vitro models of neuronal death. Trans-Clovamide is an excellent ROS and oxygen radical scavenger and also has anti-inflammatory and neuroprotective effects. Clovamide is an anti-microbial with activity against the human pathogens influenza A subtype H5N1, Trypanosoma evansi, and Heliobacter pylori.

体外活性

Clovamide protects neurons from injury in three in vitro models of neuronal death: oxidative stress, excitotoxicity and OGD/reoxygenation. In SH-SY5Y human neuroblastoma cells, Clovamide (10-100 μM) protects cell death significantly with an EC50 value of 3.6 μM. Clovamide inhibits growth of three pathogens of cacao in the genus?Phytophthora, is a substrate for cacao polyphenol oxidase, and is a contributor to enzymatic browning. Clovamide inhibits proteinase and pectinase in vitro. Clovamide also enhances PPARγ expression.

Cas No.

53755-02-5

分子式

C18H17NO7

分子量

359.33

别名

N-trans-Caffeoy-L-dopa;trans-Clovamide

储存和溶解度

DMSO:125mg/mL (347.87mM),ultrasonic and warming and heat to 60℃
Powder: -20°C for 3 years
In solvent: -80°C for 2 years