Oxytetracycline hydrochloride 是由 Streptomyces rimosus 生产的，一种具有抗菌活性的四环素衍生物。它干扰氨酰-tRNA 与 mRNA-核糖体复合物的结合，从而阻止肽延伸并抑制蛋白质合成。

Oxytetracycline Hydrochloride is a tetracycline derivative produced by Streptomyces rimosus with antimicrobial activity. It interferes with the binding of aminoacyl-tRNA to the mRNA-ribosome complex, resulting in preventing peptide elongation and inhibiting protein synthesis.

The 10-day effect of oxytetracycline at therapeutic doses (82.8 mg/kg bw to 1 % bw/day) was species-specific. Oxytetracycline increases the enzymatic activity of CYP3A4 in Ictalurus punctatus, increases the protein expression of CYP3A4 in Oreochromis niloticus, and depletes hepatic CYP3A4 in the latter, and also increases the relative liver weight of Morone chrysops x M. saxatilis [1]. Oxytetracycline is limited to 100 μg/kg in muscle and breast milk, 200 μg/kg in eggs, 300 μg/kg in liver, and 600 μg/kg in kidney[3].

2058-46-0

C22H25ClN2O9

496.89

Oxytetracycline HCl;盐酸土霉素;Dalimycin;Oxytetracycline, Sodium Salt;Oxytetracycline.HCl;Biosolvomycin;Dalinmycin

DMSO:100 mg/mL (201.25 mM)
H2O:Insoluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years