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ATI-2341 acetate(1337878-62-2 free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ATI-2341 acetate(1337878-62-2 free base)图片
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议

产品介绍
ATI-2341 acetate(1337878-62-2 free base) 是一种有效的 CXCR4 变构激动剂,它激活 Gα1 而不是 Gα13。 ATI-2341 acetate 激活抑制性异源三聚体 G 蛋白 (GI) 以促进对 cAMP 产生的抑制并诱导钙动员。

产品描述

ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13. ATI-2341 acetate activates inhibitory heterotrimeric G protein (GI) to promote the inhibition of cAMP production and induce calcium mobilization.

体外活性

ATI-2341 induced CXCR4- and G protein-dependent signaling, receptor internalization, and chemotaxis in CXCR4-expressing cells[1].

体内活性

ATI-2341 induced dose-dependent peritoneal recruitment of PMNs when administered i.p. to mice. When administered systemically by i.v. bolus, ATI-2341 acted as a functional antagonist and dose-dependently mediated release of PMNs from the bone marrow of both mice and cynomolgus monkeys[1].

Cas No.

T6764L

分子式

C106H182N26O27S2

分子量

2316.87

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years