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CDDO-dhTFEA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CDDO-dhTFEA图片
CAS NO:1191265-33-4
包装与价格:
包装价格(元)
2 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
CDDO-dhTFEA 是合成的齐墩果烷三萜化合物,可有效激活Nrf2并抑制促炎转录因子NF-Κb。 它可以恢复高血压 (MAP),提高 Nrf2 及其靶基因的表达,抑制 NF-Κb 的活化和转化生长因子-β 途径,并减少慢性肾病 (CKD) 大鼠的肾小球硬化,间质纤维化和炎症。

产品描述

CDDO-dhTFEA is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB. It restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats.

体内活性

CDDO-dhTFEA restores hypertension, increases Nrf2 and expression of its target genes, attenuates activation of NF-κB and transforming growth factor-β pathways, and reduces glomerulosclerosis, interstitial fibrosis, and inflammation in the chronic kidney disease rats [2].

Cas No.

1191265-33-4

分子式

C33H45F3N2O3

分子量

574.72

储存和溶解度

DMSO:100 mg/mL (174.00 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years