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Veliflapon
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Veliflapon图片
CAS NO:128253-31-6
包装:10 mg
市场价:8954元

产品名称
BAY X 1005
DG-031
产品介绍

产品描述

Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP). Veliflapon inhibits the synthesis of the leukotrienes B4 and C4.

体外活性

Veliflapon inhibits the synthesis of LTB4 in A23187-stimulated leukocytes from rats, mice and humans with IC50s of 0.026, 0.039 and 0.22 μM, respectively as well as the formation of LTC4 with IC50 of 0.021 μM in mouse peritoneal macrophages stimulated with opsonized zymosan[3].

体内活性

Atherogenesis inhibited by Veliflapon (DG-031; diet; 18.8 mg/kg/day for 16 weeks ). In the arachidonic acid-induced mouse ear inflammation test,Veliflapon after topical (18 μg/ear) and oral (48.7 mg/kg) administration has antiedematous effects [4]. Veliflapon is potent (11.8 and 6.7 mg/kg p.o. at 1 and 5 hours, respectively) and has a long duration of action (ED40 of 16 hours, 70 mg/kg p.o.) in the rat whole blood ex vivo leukotriene B4 inhibition assay[4].

Cas No.

128253-31-6

分子式

C23H23NO3

分子量

361.43

别名

BAY X 1005;DG-031

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years