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Etoricoxib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Etoricoxib图片
CAS NO:202409-33-4
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Tauxib
Desvenlafaxine
Arcoxia
MK-663
依托考昔
Nucoxia
L-791456
产品介绍
EtoriCOXib 是一种合成的非甾体抗炎药 (NSAID),具有解热、镇痛和潜在的抗肿瘤特性。它是可口服的选择性COX-2抑制剂,对人全血 COX-2 和 COX-1 的IC50值分别为 1.1 和 116 μM。

产品描述

Etoricoxib is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis.

体内活性

The preferential cyclooxygenase-2 inhibitor etoricoxib significantly reduces the anticonvulsant action of phenytoin and significantly increases the beneficial action of diazepam against maximal electroshock and pentylenetetrazole-induced convulsions in a mouse model[1]. Etoricoxib has the potential to act as an anti-apoptotic and anti- proliferative agent in the colon[2].

细胞实验

Human colon carcinoma cell line HCT-116 are treated with various coxibs for 2 h. Subsequently, the cells are harvested and the sphingolipids isolated and determined by LC-MS/MS. (Only for Reference)

Cas No.

202409-33-4

分子式

C18H15ClN2O2S

分子量

358.84

别名

Tauxib;Desvenlafaxine;Arcoxia;MK-663;依托考昔;Nucoxia;L-791456

储存和溶解度

DMSO:66 mg/mL (183.9 mM)
H2O:<1 mgml
Ethanol:43 mg/mL (119.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years