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Diclofenac Sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Diclofenac Sodium图片
CAS NO:15307-79-6
包装:5 mg
市场价:287元

产品名称
GP 45840
双氯芬酸钠
产品介绍
Diclofenac Sodium 是一种非选择性抗炎剂,是COX抑制剂,在 CHO 细胞中,对人 COX-1 和 COX-2 的IC50值分别为 4 和 1.3 nM。它对绵羊 COX-1 和 COX-2 的IC50值分别为 5.1 μM,0.84 μM。它通过活化 Caspase 级联反应来诱导神经干细胞凋亡。

产品描述

Diclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.

体外活性

Diclofenac inhibits Wnt/beta-catenin signaling without altering the level of beta-catenin protein and reduces the expression of beta-catenin/TCF-dependent genes. Diclofenac induces the degradation of IkappaBalpha, which increases free nuclear factor kappaB (NF-kappaB) in colon cancer cells. [1] Diclofenac suppresses both fast tetrodotoxin-sensitive (TTX-S) and the slow tetrodotoxin-resistant (TTX-R) sodium currents in a dose-dependent manner. Diclofenac produces shifts of the steady-state inactivation curves in the hyperpolarizing direction in both types of sodium currents in a dose-dependent manner. Diclofenac may bind to sodium channels with a greater affinity when they are in the inactivated state than when they are in the resting state. [2] Diclofenac results in a severe accumulation of protein in the tubular cells (so called hyaline droplet degeneration), macrophage infiltration and structural alterations (dilation, vesiculation) of the endoplasmic reticulum (ER) in the proximal and distal renal tubules of kidney. Diclofenac also results in shortening of podocytes and their retraction from the basal lamina, a thickening of the basal lamina, the formation of desmosomes, and necrosis of endothelial cells in the renal corpuscles of kidney. [3]

体内活性

Diclofenac (0.01 to 0.2 mM) stimulates state-4 respiration and slightly inhibits state 3 in rats, decreasing the respiratory control ratio, while the membrane potential is decreased or collapsed (depending on the drug concentration). [4]

Cas No.

15307-79-6

分子式

C14H10Cl2NNaO2

分子量

318.13

别名

GP 45840;双氯芬酸钠

储存和溶解度

DMSO:31.8 mg/mL (100 mM)
H2O:15.9 mg/mL (50 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years