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Parecoxib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Parecoxib图片
CAS NO:198470-84-7
包装与价格:
包装价格(元)
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
SC 69124
帕瑞昔布
Valus-P
Vorth-P
产品介绍
PareCOXib 是一种有效的选择性 COX-2 抑制剂,是 ValdeCOXib 的前药。

产品描述

Parecoxib is an effective and selective COX-2 inhibitor.

体内活性

Parecoxib, a selected cyclooxygenase-2 inhibitor, ameliorates neurologic deficits in the behavior studies and brain damage, including neuronal death, and brain edema in the MCP-1 and NeuN immunostaining in rats subjected to SAH(Subarachnoid Hemorrhage). Parecoxib is able to reduce early COX2 expression via inhibiting cJNK (p55) expression (dose-dependently), reduce IL-1β, IL-6 and MCP-1( at 2000 ug/kg/day at the time point of 24hr and 72hr after the induction of SAH), IL-8 (of the dosage of 2000 ug/kg/day at 24hr after the induction of SAH), and also reduce cleaved caspase-1 (at 1000 and 2000 ug/kg/day) and Caspase-9a (at 2000 ug/kg/day). Parecoxib reduces the NMDAR-1, and NMDAR-2a (at 1000 and 2000 ug/kg) after the induction of SAH[2].

Cas No.

198470-84-7

分子式

C19H18N2O4S

分子量

370.42

别名

SC 69124;帕瑞昔布;Valus-P;Vorth-P

储存和溶解度

Ethanol:2 mg/mL (5.4 mM)
H2O:<1 mgml
DMSO:69 mg/mL (186.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years