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Imrecoxib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Imrecoxib图片
CAS NO:395683-14-4
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
艾瑞昔布
BAP-909
产品介绍
ImreCOXib 是COX1和COX2的抑制剂,IC50值为 115 和 18 nM,具有抗炎作用。

产品描述

Imrecoxib is a novel and selective cyclooxygenase 2 (COX-2) inhibitor (IC50: 18 nM). It also inhibits COX1- activity (IC50: 115 nM). Imrecoxib has an anti-inflammatory effect.

体外活性

In U937 cells, Imrecoxib (0.1-10 μM; 24 hours) reduces COX-2 mRNA level induced by PMA+LPS in a dose-dependent manner.

体内活性

Imrecoxib (gastrointestinal administration; 5-20 mg/kg; started on day 7; 26 days) diminishes the secondary paw swelling. It also inhibits heat-inactivated BCG induced-inflammtory polyarthritis. Imrecoxib (gastrointestinal administration; 5-20 mg/kg; 1 hour before carrageenan injection) suppresses carrageenan-induced acute inflammation, and the inhibitory effect is maximal at 4 hours.

Cas No.

395683-14-4

分子式

C21H23NO3S

分子量

369.48

别名

艾瑞昔布;BAP-909

储存和溶解度

DMSO:90 mg/mL (243.59 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years