VAF347 是细胞可渗透且高度亲和力的芳烃受体激动剂，可诱导AhR信号传导，具有抗炎作用。它抑制颗粒单核细胞 (GM 期) 前体中 CD14+CD11b+单核细胞的发育。

VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.

In HL-60 cells, VAF347 augments retinoic acid-induced expression of AhR, Lyn, Vav1, and c-Cbl as well as p47phox. Several interactions of the partners in the signal body appear to be enhanced: Fgr interacts with c-Cbl, CD38, and pS259c-Raf, and AhR interacts with c-Cbl and Lyn[1]. VAF347 enhances retinoic acid-induced cell cycle arrest[1].

AhR-deficient mice are resistant to VAF347's ability to block allergic lung inflammation in vivo[2].

574759-62-9

C17H11ClF3N3

349.74

4-(3-氯苯基)-N-[4-(三氟甲基)苯基]嘧啶-2-胺

DMSO:10 mg/mL (71.48 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years