AF 12198 Acetate 是一种新型的低分子量 IL-1 拮抗剂。

AF 12198 Acetate is a novel low molecular weight antagonist of IL-1

?In vitro, AF12198 inhibits IL-1-induced IL-8 production by human dermal fibroblasts with a half-maximal inhibition concentration or IC50 of 25 nM and IL-1-induced intercellular adhesion molecule-1 (ICAM-1) expression by endothelial cells with an IC50 of 9 nM[1].

When given as an intravenous infusion to cynomolgus monkeys, AF12198 blocks ex vivo IL-1 induction of IL-6 and down modulates in vivo induction of IL-6.?This is the first small molecule to show IL-1 receptor antagonist activity in vivo[1].?

T21644L

C98H127N19O24

1955.17

AF 12198 Acetate (185413-30-3 Free base)

DMSO:60 mg/ml (30.69 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years