Angoline 是选择性IL6/STAT3信号通路的抑制剂，IC50为 11.56 μM。它抑制 STAT3 磷酸化及其靶基因表达，并抑制癌细胞增殖。

Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor(IC50 : 11.56 μM). It inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation.

Angoline as a potent and selective inhibitor of the STAT3 signaling pathway (IC50=11.56 μM).?Angoline inhibited STAT3 phosphorylation and its target gene expression and consequently induced growth inhibition of human cancer cells with constitutively activated STAT3 (IC50=3.14-4.72 μM).?This work provided a novel lead for the development of anti-cancer agents targeting the STAT3 signaling pathway.

21080-31-9

C22H21NO5

379.412

6-Methoxyldihydrochelerythrine

DMSO:30 mg/ml (79.07 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years