Sodium butanOATe 是具有潜在抗肿瘤活性的butyrate钠盐。Butyrate是一种短链脂肪酸，与 I 类和 II 类组蛋白脱乙酰酶 (HDAC) 的锌位点竞争性结合。

Sodium Butyrate is the sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs).

Sodium butyrate能够增加组蛋白和特异性蛋白-1乙酰化,同时抑制3-硝基丙酸产生神经毒性.在亨廷顿氏病的R6 /2转基因小鼠模型中,Sodium butyrate能够延缓后遗症的发作和延长生存周期.

在结肠粘膜中,Sodium butyrate能够产生抗炎和抗癌作用,降低氧化应激,从而抑制结肠癌细胞的生长。在RG / C2和AA / Cl腺瘤细胞系中,Sodium butyrate能够诱导细胞产生凋亡。

Cells are seeded at a density of 2,000 cells/well in 96-well plates with 200 μL culture medium containing Sodium Butyrate at different concentrations. Then, the cells are consecutively cultured for 72 h. Every 24 h, 20 μL 5 mg/mL MTT solution is added into the corresponding well, and the cells are cultured for another 4 h. Then, the solution is replaced with 150 μL dimethylsulfoxide, followed by gentle agitation of the plates for 15 min at room temperature. Finally, the absorbance at 492 nm is measured to represent the cell viability.

156-54-7

C4H7NaO2

110.088

丁酸钠;Butanoic acid sodium salt;Sodium Butyrate

H2O:100 mg/mL (908.35 mM),need ultrasonic
DMSO:10 mM,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years