QuetIAPine 是5-HT受体激动剂和多巴胺受体拮抗剂，对人5-HT1A的pEC50值为 4.77，对人D2的pIC50值为 6.33。它用于治疗精神分裂症，以及治疗与 I 型双相情感障碍相关的急性躁狂发作。它对人D2、HT1、5-HT2A、5-HT2C受体具有中高等亲和力，pKi值为 7.25、5.74、7.54和5.55。

Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antagonist activity at serotonin and dopamine receptors. Specifically, the D1 and D2 dopamine, the α1 adrenoreceptor and α2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also can inhibit the histamine H1 receptor.

111974-69-7

C21H25N3O2S

383.51

ICI204636;Quetiapin;喹硫平

H2O:<1 mgml
DMSO:36 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years